Please use this identifier to cite or link to this item: https://dspace.univ-ouargla.dz/jspui/handle/123456789/31606
Title: EFFET HEPATO-PROTECTEUR D’EXTRAITS BRUTS DE POLYSACCHARIDES DE FEUILLES D’Oudneya africana R. Br. (BRASSICACEAE) SUR L'INFLAMMATION AIGUË INDUITE PAR L'ACETATE DE PLOMB CHEZ DES RATS Wistar albino
Authors: MEHELLOU Zineb
YOUMBAI Asma
BOUAL Zakaria
GARDARIN Christine
PIERRE Guillaume
DELATTRE Cédric
MICHAUD Philippe
OULD EL HADJ Med Didi
Keywords: Water-soluble polysaccharides
Oudneya africana R Br
hepatoprotective effect
lead acetate
Wistar albino
Issue Date: 30-Jun-2022
Series/Report no.: vol. 12, n°1, Juin 2022;
Abstract: This work focuses on the study of polysaccharides from the leaves of Oudneya africana R. Br. (Brassicaceae), a spontaneous plant with a medicinal character harvested in the region of M'Rara wilaya of El Oued (northern Algerian Sahara). The extraction of water-soluble polysaccharides (PHOA) gave a mass yield of 7.24%. The determination of the composition of PHOA obtained, by colorimetric assays, indicates levels of 50.63±0.07% in total sugars, 47.95±0.002% in neutral sugars and 21.20±0.001% in proteins. Analysis of the monosaccharide composition by high performance anion exchange chromatography coupled with a pulsed amperometric detector (HPAEC-PAD) found the presence of L-arabinose (11.4%), D-galactose (13.3%), D-glucose (19.7%), D-mannose (46%), D-galacturonic acid (8.3%), and D-glucuronic acid (1%). The study of the hepatoprotective activity of the extract is carried out in vivo on male and female rats of the Wistar albino strain by oral poisoning with lead acetate. At a concentration of 100mg/kg, the PHOA fraction shows antioxidant activity by significant suppression of the increase in malondialdehyde (MDA) levels and the decrease in reduced glutathione (GSH) levels in liver and kidney tissues observed after exposure to lead. Histopathological analysis of the livers indicates that PHOA has a hepatoprotective effect in female rats while they note a decrease in the intensity of hepatotoxicity in males, which makes them a potential agent for the prevention of liver damage
Description: Algerian journal of arid environment
URI: https://dspace.univ-ouargla.dz/jspui/handle/123456789/31606
ISSN: 2170-1318
Appears in Collections:volume 12 numéro 1 2022

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