Bioactive substance produced by lactic acide bacteria (LAB) against pathogenic bacteria

Abstract

The objective of this work was to study the antagonistic power of 19 strains of lactic acid bacteria, vis-à-vis multi-resistant strains. For this and initially, the spot test and the well test are implemented. These tests revealed the inhibitory activity of the lactic acid bacteria strains tested against the target strains by their power to produce antimicrobial substances. Secondly, a test of the antibiofilm effect is carried out between the MDRs and the culture supernatant of the lactic acid bacteria. It is concluded that the bacteriocins produced by L. raffinolactis (LAB14) and Leuconostoc mesenteroides subsp. cremoris (LAB86) exhibit therapeutic potential against pathogenic bacteria forming biofilm, which contributes to pathogenicity and antibiotic resistance

انهدف مه هذا انعمم هى دراست انخأثٍز انمضبد نـ19وىع مه بكخٍزٌب حمض انلاكخٍك ضد سلالاث مخعددة انمقبومت. أولا ً حم إخزاء إخخببر ٌه و هم إخخببر انبقعت و إخخببر انبئز ، و كشف هذ ٌه الإخخببر ٌه عه انىشبط انمثبظ نـسلالاث حمض انلاكخ ٍك ضد انسلالاث انمسخهدفت مه خلال قدرحهب عهى إوخبج مىاد مضبدة نهم ٍكزوببث ثبو ًٍب ، ٌخم إخزاء اخخببر نخأث ٍز انمضبد انح ٍىي ب ٍه سلالاث مخعددة انمقبومت و محهىل بكخٍزٌب حمص انلاكخٍك انطبف ً و وسخىخح أن انبكخزٌىسٍىبث انخ ً حىخدهب انبكخٍزٌبL.raffinolactis (LAB14)وLeuconostoc mesenteroidessubspو قد عزضج بكخٍزٌبcremoris (LAB86)انقدرة انعلاخٍت فٍمب ٌخعهق ببنبكخٍزٌب انمسببت نلأمزاض انخ ً حشكم الأغشٍت انحٍىٌت ، وانخ ً حسبهم ف ً الأمزاض ومقبومت انمضبداث انحٍىٌت