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Title: | EVALUATION OF THE CHEMOPREVENTION EFFECTS OF RUTIN TOWARDS THE HEMATOTOXICITY OF THE ANTICANCEROUS DRUG CYTARABINE IN VIVO USING BALB C MICE |
Authors: | Chafia, Tigrine Hamama, Bouriche Abdelkarim, Kameli Khaled, Kharraz Mohammed, Mahdid |
Keywords: | Flavonoids rutin chemotherapy cytarabine cancer chemoprevention |
Issue Date: | 16-Nov-2016 |
Abstract: | Rutin, a natural flavone derivative, quercetin-3-O-rhamnosylglucoside, is known for its pharmacological properties. In the present study, the chemo preventive effect of rutin towards the hematotoxicity caused by the anticancerous drug cytarabine is studied in vivo using Balb C mice. The analysis of the blood numeration formula showed that the administration of a single dose of cytarabine (100 mg/m2, subcutaneous injection) caused a significant myelodepression mainly after 24 (p ≤ 0.1) and 48 (p ≤ 0.05) hours of cytarabine subcutaneous injection. Thus, the number of the red and white cells decreased in a remarkable way. However, the number of these cells increased after 72 hours which means the degradation and elimination of cytarabine. On the other hand, the administration of a daily amount of rutin (100 mg/kg, intraperitoneal injection) during 4 days before cytarabine subcutaneous injection did not exert any cytotoxic effects on the blood cells. Moreover, the combination rutin/cytarabine protected, as well as, the red and the white cells from the toxicity of cytarabine. The number of these cells is comparable with that of the control group. |
Description: | Le 2ème Séminaire International sur les Plantes Médicinales SIPM'2 |
URI: | http://dspace.univ-ouargla.dz/jspui/handle/123456789/12337 |
Appears in Collections: | 3. Faculté des sciences appliquées |
Files in This Item:
File | Description | Size | Format | |
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Chafia Tigrine.pdf | 93,04 kB | Adobe PDF | View/Open |
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