تحضیر ودراسة التفاعلیة الكیمیائیة لمشتقات الألكیلیدین بیتونولید وفعالیتھا البیولوجیة

Abstract

Butenolides are a class of lactones with a four carbon heterocyclic ring structure. They are sometimes considered as oxidized derivatives of furan. The 2-furanone, which is a common component of larger simplest butenolide is natural products and is sometimes referred to as simply "butenolide". A common biochemically important butenolide is ascorbic acid (vitamin C). The butenolide and their analogues represent a wide range of the natural compounds of medical and biological importance. In the last decades, a great number of compounds of various structures, in general from Alkylidene butenolide were isolated and showed biological activities. In this work we have studied the reactivity of some alkylidenes butenolides using the 1,6- addition of cuprates and carried out their antibacterial activity