Please use this identifier to cite or link to this item:
https://dspace.univ-ouargla.dz/jspui/handle/123456789/23550
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | دريد, محمد الحبيب | - |
dc.contributor.author | صخري, لخضر | - |
dc.date.accessioned | 2020-09-15T10:00:44Z | - |
dc.date.available | 2020-09-15T10:00:44Z | - |
dc.date.issued | 2020-07-02 | - |
dc.identifier.uri | http://dspace.univ-ouargla.dz/jspui/handle/123456789/23550 | - |
dc.description.abstract | The development of methods and mechanisms for safe and clean reduction is still a vast area for scientific researches. In 1997 N. J. Lawrence; L. Sekhri and co-workers reported the convenient procedure for the reduction of esters, Carboxylic acids, ketones, and aldehydes using tetrabutyl- ammonium fluoride (TBAF) and polymethylhydrosiloxane (PMHS) to the corresponding alcohols. We now found that the same transformation as a mild, environmentally friendly method for reduction of can be achieved with a range of α-aminoacids (1a-1h) which have been converted efficiently to the corresponding β-aminoalcohols: 2-amino-3-methylpentan-1- ol [isoleucinol (2a)], 2-amino-4-(methylthio)butan-1-ol [methioninol (2b)], 2-amino-3- methylbutan-1-ol [valinol (2c)], 2-amino-3-(4’-hydroxyphenyl) propan-1-ol [tyrosinol (2d)], 2-amino-3-phenylethan-1-ol [phenylglycinol (2e)], 2-amino-3-phenylpropan-1-ol [phenylalaninol (2f)], 2-aminoethan-1-ol [glycinol (2g)], and 2-aminopropanol-1-ol [alaninol (2h)], with polymethylhydrosiloxane, PMHS, in the presence of catalytic tetrabutylammonium fluoride, TBAF with > 61% yield. Carboxylic acid derivatives such as amides (3a and 3b) have also been reduced to the corresponding amines: N-ethylaniline (4a) and N-methylaniline (4b) with polymethylhydrosiloxane, PMHS, in the presence of catalytic tetrabutylammonium fluoride, TBAF with > 74% yield. We also found that this transformation can be achieved for the reduction of aromatic nitro compounds to the corresponding amines. A range of aromatic nitro compounds such as (m-Nitroaniline 5a and p-Nitroaniline 6a) have been converted efficiently to the corresponding aromatic amines: 1, 3-diaminobenzene (5b), and 1,4-diaminobenzene (6b) with > 61% yield. The resulting products were identified by comparison their spectra with those of authentic samples | en_US |
dc.description.sponsorship | L’UNIVERSITE KASDI MERBAH- OUARGLA FACULTE DES MATHEMATIQUES ET SCIENCES DE LA MATIERE DÉPARTEMENT DE CHIMIE | en_US |
dc.language.iso | other | en_US |
dc.relation.ispartofseries | ;2020 | - |
dc.subject | Reduction | en_US |
dc.subject | amino acids | en_US |
dc.subject | amides | en_US |
dc.subject | nitro compounds | en_US |
dc.subject | polymethylhydrosiloxane( PMHS) | en_US |
dc.subject | tetrabutylammonium fluoride (TBAF) | en_US |
dc.title | دراسات لإرجاع الاحماض الامنية الطبيعية والاميدات مثل البيرولدينات ومركبات تحتوي علي مجموعة النترو باستعمال متعدد المثيل هيدروسلوكسان ورباعي البيوتيل أمونيوم فلوريد | en_US |
dc.title.alternative | Studies on the reduction of natural aminoacids, amides such as pyrrolidines, compounds containing nitro group using tetrabutylammonium fluoride and polymethylhydrosiloxane | en_US |
dc.type | Thesis | en_US |
Appears in Collections: | département de physique Mastériales |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
محمد الحبِيب دريد.pdf | 6,52 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.