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|Title:||The asymmetric reduction of prochiral ketones using tetrabutylammonium fluoride, polymethylhydrosiloxane and biocatalysts, baker's yeast|
|Authors:||M.S.NEDJIMI, and Lakhdar SEKHRI|
|Abstract:||A range of prochiral acetophenone derivatives have been converted efficiently to the corresponding (R)- alcohols with > 80% yield and good enantioselectivities (up to 70% ee). Cyclic ketones are also reduced with high levels of stereoselectivity with PMHS in the presence of TBAF and baker's yeast, in particular 4-methylcyclohaxanone (trans: cis 84:16). High stereoselectivity is also observed in the reduction of 2-cyanobenzaldehyde and anti- imine was obtained in 71%.|
|Description:||1st International Days of Organometallic Chemistry and Catalysis JICOC Ouargla, February 06- 09, 2012|
|Appears in Collections:||1. Faculté des mathématiques et des sciences de la matière|
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