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Title: The asymmetric reduction of prochiral ketones using tetrabutylammonium fluoride, polymethylhydrosiloxane and biocatalysts, baker's yeast
Authors: M.S.NEDJIMI, and Lakhdar SEKHRI
Keywords: asymmetric reduction
backer's yeast
Issue Date: 19-Dec-2013
Series/Report no.: 2012;
Abstract: A range of prochiral acetophenone derivatives have been converted efficiently to the corresponding (R)- alcohols with > 80% yield and good enantioselectivities (up to 70% ee). Cyclic ketones are also reduced with high levels of stereoselectivity with PMHS in the presence of TBAF and baker's yeast, in particular 4-methylcyclohaxanone (trans: cis 84:16). High stereoselectivity is also observed in the reduction of 2-cyanobenzaldehyde and anti- imine was obtained in 71%.
Description: 1st International Days of Organometallic Chemistry and Catalysis JICOC Ouargla, February 06- 09, 2012
ISSN: saf
Appears in Collections:1. Faculté des mathématiques et des sciences de la matière

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