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Title: | The asymmetric reduction of prochiral ketones using tetrabutylammonium fluoride, polymethylhydrosiloxane and biocatalysts, baker's yeast |
Authors: | M.S.NEDJIMI, and Lakhdar SEKHRI |
Keywords: | asymmetric reduction biocatalyst backer's yeast TBAF PMHS |
Issue Date: | 19-Dec-2013 |
Series/Report no.: | 2012; |
Abstract: | A range of prochiral acetophenone derivatives have been converted efficiently to the corresponding (R)- alcohols with > 80% yield and good enantioselectivities (up to 70% ee). Cyclic ketones are also reduced with high levels of stereoselectivity with PMHS in the presence of TBAF and baker's yeast, in particular 4-methylcyclohaxanone (trans: cis 84:16). High stereoselectivity is also observed in the reduction of 2-cyanobenzaldehyde and anti- imine was obtained in 71%. |
Description: | 1st International Days of Organometallic Chemistry and Catalysis JICOC Ouargla, February 06- 09, 2012 |
URI: | http://hdl.handle.net/123456789/2815 |
ISSN: | saf |
Appears in Collections: | 1. Faculté des mathématiques et des sciences de la matière |
Files in This Item:
File | Description | Size | Format | |
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M.S.NEDJIMI.pdf | 93,9 kB | Adobe PDF | View/Open |
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