Iron chelating activity of dithiolethiones compounds

Abstract

Transition metal ions have a great importance in the generation of oxygen free radicals in living organisms. Iron exists in two distinct oxidation states; ferrous ion (Fe2+) and ferric ion (Fe3+). The ferric ion (Fe3+) is the relatively biologically inactive form of iron. However, it can be reduced to the active Fe2+, depending on the conditions, particularly pH [1], and oxidized back through Fenton type reactions, with production of hydroxyl radicals; or Haber- Weiss reactions with superoxide anions [2]. The production of these radicals can lead to lipid peroxidation, protein modification and DNA damage.

In this study, the chelating of ferrous ions by different dithiolethiones [PDTT (CH3SO4-)], [PDTT], [TDTT(I-)], [TDTT(CH3SO4-) ,[PDTT(I-)] and Ascorbic Acid was estimated by the phenantroline assay. Phenanthroline can quantitatively form complexes with Fe2+.

The results show that The metal scavenging effect of those samples decreased in the order of [PDTT(CH3SO4-)]>[PDTT]> Ascorbic Acid >[TDTT(I-)]>[TDTT(CH3SO4-)>[PDTT(I-)]