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Title: | Iron chelating activity of dithiolethiones compounds |
Authors: | Zehour RAHMANI, Mokhtar SAIDI, Messouda DAKMOUCHE, Salma CHABIAa |
Keywords: | dithiolethiones compounds |
Issue Date: | 19-Dec-2013 |
Series/Report no.: | 2012; |
Abstract: | Transition metal ions have a great importance in the generation of oxygen free radicals in living organisms. Iron exists in two distinct oxidation states; ferrous ion (Fe2+) and ferric ion (Fe3+). The ferric ion (Fe3+) is the relatively biologically inactive form of iron. However, it can be reduced to the active Fe2+, depending on the conditions, particularly pH [1], and oxidized back through Fenton type reactions, with production of hydroxyl radicals; or Haber- Weiss reactions with superoxide anions [2]. The production of these radicals can lead to lipid peroxidation, protein modification and DNA damage. In this study, the chelating of ferrous ions by different dithiolethiones [PDTT (CH3SO4-)], [PDTT], [TDTT(I-)], [TDTT(CH3SO4-) ,[PDTT(I-)] and Ascorbic Acid was estimated by the phenantroline assay. Phenanthroline can quantitatively form complexes with Fe2+. The results show that The metal scavenging effect of those samples decreased in the order of [PDTT(CH3SO4-)]>[PDTT]> Ascorbic Acid >[TDTT(I-)]>[TDTT(CH3SO4-)>[PDTT(I-)] |
Description: | 1st International Days of Organometallic Chemistry and Catalysis JICOC Ouargla, February 06- 09, 2012 |
URI: | http://hdl.handle.net/123456789/3150 |
ISSN: | saf |
Appears in Collections: | 1. Faculté des mathématiques et des sciences de la matière |
Files in This Item:
File | Description | Size | Format | |
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Zehour RAHMANI.pdf | 157,68 kB | Adobe PDF | View/Open |
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